Table 1. Representative enriched motifs identified by Clover.

All sequences bound by dFOXO
Motif	TF	Raw score	P *
For the comprehensive lists please refer to Supplementary information.
aRelative to wild type.
bRelative to daGAL4>UAS-dInRDN.
*Relative to whole chromosome 2L.
**Relative to all sequences bound by dFOXO.
***Relative to all promoter sequences of the genes present on the expression arrays.
VCGCYGCMGYCGCTGMCNGCG	ADF1	665	<10−3
WWWRTAAASAWAA	BRCZ4	659	<10−3
WNTATAAACAWNNR	XFD2	222	<10−3
dFOXO-bound and gene(s) downregulated in dfoxoΔ/Δ a
Motif	TF	Raw score	P **
NNNGCCASCAGRKGGCRSNN	CTCF	117	<10−3
TRTAAACAANWN	FOXO3A	104	0.003
dFOXO-bound and gene(s) upregulated in dfoxoΔ/Δ a
Motif	TF	Raw score	P **
WWWRTAAASAWAA	BRCZ4	75.2	<10−3
TRTAAACAANWN	FOXO3A	56.7	<10−3
dFOXO-bound and gene(s) downregulated in dfoxoΔ/Δ daGAL4>UAS-dInRDN b
Motif	TF	Raw score	P **
NNNGCCASCAGRKGGCRSNN	CTCF	271	<10−3
TRTAAACAANWN	FOXO3A	208	<10−3
dFOXO-bound and gene(s) upregulated in dfoxoΔ/Δ daGAL4>UAS-dInRDN b
Motif	TF	Raw score	P **
NWAAACAAN	FOXO1	63.5	<10−3
TRTAAACAANWN	FOXO3A	57.8	0.002
Promoters of genes downregulated in daGAL4>UAS-dInRDN indirectly dependent on dfoxo
Motif	TF	Raw score	P ***
NNWGATAASA	GATA2	80	<10−3
MNAGATAANR	GATA1	39.9	<10−3
Promoters of genes upregulated in daGAL4>UAS-dInRDN independent of dfoxo
Motif	TF	Raw score	P ***
NNNWAAAYAAAYANNNNN	FOXJ2	115	0.004
WWWRTAAASAWAA	BRCZ4	110	<10−3
Promoters of genes downregulated in daGAL4>UAS-dInRDN independent of dfoxo
Motif	TF	Raw score	P ***
NNWGATAASA	GATA2	8.11	<10−3
NCWGATAACA	GATA1	4.77	0.003