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Interobserver Variation: Cases with interobserver agreement in diagnosis (N = number of cases with all three participant pathologists agreeing on the diagnosis, Total = 60 cases).
| Diagnosis | H&E (kappa) | H&E+p16 and Ki67 (kappa) |
|---|---|---|
| Negative | 6 (0.42) | 13 (0.59) |
| Low grade AIN | 7 (0.32) | 7 (0.35) |
| High grade AIN | 11 (0.61) | 15 (0.75) |
| Overall weighted kappa | 0.45 | 0.57 |
