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. 2008 Mar 1;1:17–34. doi: 10.4137/cpath.s487

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This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license http://creativecommons.org/licenses/by/3.0/).

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Figure 3. — Comparison of the two estrogen receptor molecules. The estrogen receptor consists of six functional domains. Estrogens manifest their biological activity through two distinct receptors, ERα and ERβ. The numbers in the boxes indicate numbers of amino acids. Homology between the distinct domains of the receptors is indicated. It is believed that the binding of different ligands induces structural alterations within the estrogen receptor and that the cells differ in their ability to recognize these conformations. TAF: transcription activating function.