Table 1.
Systemic administration of drugs that act on the histaminergic system and memory performance.
| Species | Histaminergic modulator delivery route | Behavioral task | Histaminergic modulator | Lesion or pharmacological induced memory impairment | Effect on memory | Reference(s) |
|---|---|---|---|---|---|---|
| Rat | i.p. | Radial maze | Histidine | scopolamine (intrahippocampal) |
↑ | [77] |
| Rat | i.p. | Eight-arm radial maze | Histidine | MK-801 (intrahippocampal) |
↑ | [78] |
| Rat | i.p. | Delayed non-matching to position (DNMTP) task | H3 receptor antagonist (JNJ-10181457) | Scopolamine (i.p.) | ↑ | [79] |
| Rat | i.p. | Radial maze | Histidine | Muscimol (intraseptal) | ↑ | [80] |
| Rat | i.p. | Object recognition | H1 receptor antagonist (ciproxifan) | Scopolamine (i.p.) | ↑ | [81] |
| Mouse | i.p. | Object recognition | H3 receptor inverse agonist (BF 2649) | Scopolamine (i.p.) | ↑ | [82] |
| Rat | i.p. | Passive avoidance | H3 receptor antagonist (compound 5) | Scopolamine (s.c.) | ↑ | [83] |
| Rat | Oral administration | Passive avoidance | H3 receptor antagonist (GSK207040 and GSK334429) | Scopolamine (i.p.) | ↑ | [84] |
| Mouse | i.p. | Step-through inhibitory avoidance | H3 receptor antagonist (thioperamide) | scopolamine or dizocilpine (i.p.) | ↑ | [85] |
| Mouse | i.p. | Step-through passive avoidance | H3 receptor antagonist (clobenpropit, thioperamide) | scopolamine (i.p.) | ↑ | [86, 87] |
| Mouse | i.p. | Plus maze | Histidine | Scopolamine (i.p.) | ↑ | [88] |
| Mouse | i.p. | Plus maze | H3 receptor antagonist (thioperamide) | Scopolamine (i.p.) | ↑ | [89] |
| Mouse | i.p. | Plus maze | H3 receptor antagonist (FUB 181 [3-(4-chlorophenyl)propyl-3-(1H-imidazol-4-yl)propyl ether]) | scopolamine (i.p.) | ↑ | [90, 91] |
| Rat | s.c. | Inhibitory avoidance | H3 receptor antagonists (GT-2331, ciproxifan, A-304121, A-317920; ABT-239) | ↑ | [92–94] | |
| Mouse | i.p. | Step-through inhibitory avoidance | H3 receptor antagonist (thioperamide) | ↑ | [85] | |
| Mouse | i.p. | Passive avoidance | H3 receptor antagonist (thioperamide) | ↑ | [95] | |
| Rats | i.p. | Object recognition Passive avoidance | H3 receptor agonists (RAMH, imetit, immepip) | ↓ | [96] | |
| Rat | Oral administration. | Active avoidance | H1 receptor antagonists (diphenhydramine, pyrilamine, promethazine and chlorpheniramine) | ↓ | [97] | |
| Rat | i.p. | Inhibitory avoidance | H1 receptor antagonist (chlorpheniramine) |
↑ | [98] | |
| Rat | i.p. | Water maze | Histidine | no effect | [99] | |
| Rat | i.p. | Water maze | H3 receptor agonist, (RAMH) | ↑ | [99] | |
| Rat | i.p. or oral administration | Social memory | H3 receptor antagonists (ABT-239) | ↑ | [94] |
RAMH: (R)-alpha-methylhistamine (H3 receptor agonist); i.p.. intraperitoneal; s.c.: subcutaneous.