Table 3.

Intracerebroventricular administration of drugs that act on the histaminergic system and memory performance.

Species	Behavioral task	Histaminergic modulator	Lesion or pharmacological induced memory impairment	Effect on memory	Reference(s)
Rat	Passive avoidance	Histamine		↑	[120, 121]
Rat	Passive avoidance	Histamine		↓	[122–124]
Mouse	Passive avoidance	Histamine	Lithium (i.p.)	↑	[125]
Rat	Active avoidance	Histamine		↑	[126]
Rat	Active avoidance	Histamine		↓	[127]
Rat	Active avoidance	Histamine	Bilateral hippocampectomy (dorsal hippocampus)	↑	[128]
Rat	Active avoidance	Histamine	alpha-FMH (i.p.)	↑	[126]
Rat	Habituation in open field	Histamine		↑	[121]
Rat	Social memory	Histamine		↑	[129]
Rat	Social memory	Histidine		↑	[129]
Rat	Social memory	alpha-FMH		↓	[129]
Rat	Radial maze	Histamine	N-methyl- d-aspartate (NMDA) receptor glycine site antagonist (7-chlorokynurenic acid) i.c.v	↑	[130]
Rat	Radial maze	alpha-FMH		↓	[131]
Rat	Passive avoidance	H1 receptor antagonist (chlorpheniramine)		↑	[122]
Rat	Passive avoidance	H1 receptor antagonist (pyrilamine )		↑	[124]
Rat	Passive avoidance	H2 receptor antagonist (cimetidine)		↑	[123, 124]
Mouse	Passive avoidance	H2 receptor agonist (4-methylhistamine)		↓	[90]
Rat	Active avoidance	H1 receptor agonist (2-methylhistamine and 2-thiazolylethylamine)		↓	[127]
Rat	Step-through active avoidance	H1 receptor agonist (2-methylhistamine)		↑	[132]
Rat	Step-through active avoidance	H1 receptor antagonist (pyrilamine or diphenhydramine)		↓	[132]
Rat	Social memory	H3 receptor agonist (immepip)		↓	[129]
Rat	Social memory	H3 receptor antagonist (thioperamide)		↑	[129]
Rat	Object recognition	H1 receptor agonist [2-(3-(trifluoromethyl)-phenyl)histamine]		↑	[133]
Rat	Water maze	H1 receptor antagonist (chlorpheniramine)		↑	[134]

alpha-FMH: alpha-fluoromethylhistidine (inhibitor of histamine decarboxylase)

i.p. intraperitoneal

i.c.v intracerebroventricular.