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. 2011 Sep 15;138(18):3879–3884. doi: 10.1242/dev.069336

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Fig. 3. — mir-7 expression and function during hematopoiesis. (A) mir-7 enhancer-GFP transgene is expressed in the medullary zone and PSC cells in control Drosophila lymph glands. (B) mir-7 mutant lymph glands possess a diminished medullary zone as marked by dome-lacZ. (C) mir-7 mutant lymph glands present with an overproduction of plasmatocytes (marked by P1) and lamellocytes (marked by MSNF9-mCherry). (D) Immunostaining with P1 antibody and expression pattern of TepIVGal4-driven GFP in a control lymph gland. (E) Forced expression of mir-7 in hematopoietic progenitors results in medullary zone expansion and plasmatocyte reduction. (E′) Expanded pattern of Bam protein accumulation in a mir-7 gain-of-function lymph gland. (F) Double-heterozygous combination of mir-7^Δ¹ and bam^Δ⁸⁶ alleles results in a lymph gland devoid of prohemocytes. MZ, medullary zone; PSC, posterior signaling center.