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Confidence interval visual predictive check plots of the selected structural and variability model including the dose effect, on a semi-log scale. The 90% confidence interval around the 5th, 50th, and 95th prediction percentiles from 250 simulated datasets are overlaid on the observed 5th, 50th, and 95th percentiles for the parent drug (top) and the metabolite (bottom) at W4 and W8 for a dose of a 5, b 10, and c 20 mg
