Table III.

Between-Subject Standard Deviation

ωF ap			ωK ap		ωK am		ωV p (= ωV m)a		ωCL apo		ωCL apm		ωCL amo		ωCL amp
Without interconversion	FOCE-I ODE	–	–	0.05	NE	–	–	0.21	NE	2.04	NE	0.30	NE	0.51	NE	–	–
	CF	–	–	0.06	NE	–	–	0.20	NE	1.70	NE	0.29	NE	0.51	NE	–	–
	SAEM ODE	–	–	2.18	47	–	–	0.28	14	1.46	12	0.30	15	0.44	10	–	–
	CF	–	–	1.60	61	–	–	0.31	13	1.60	18	0.37	12	0.52	8	–	–
With interconversion	FOCE-I ODE	–	–	3.35	NE	–	–	0.27	NE	0.95	NE	0.20	NE	0.60	NE	0.05	NE
Without first-pass effect	CF	–	–	0.04	NE	–	–	0.25	NE	0.88	NE	0.21	NE	0.60	NE	0.00	NE
	SAEM ODE	–	–	2.66	39	–	–	0.23	17	1.09	12	0.21	27	0.62	9	0.31	40
	CF	–	–	2.94	46	–	–	0.31	12	0.98	13	0.24	22	0.59	9	0.28	50
With first-pass effect	FOCE-I ODE	–	–	0.01	NE	0.32	NE	0.28	NE	0.55	NE	0.02	NE	0.90	NE	0.01	NE
Without dose apportionment	CF	–	–	0.01	NE	0.29	NE	0.28	NE	0.55	NE	0.05	NE	0.87	NE	0.01	NE
	SAEM ODE	–	–	0.66	70	0.66	57	0.30	12	1.12	13	0.20	30	0.55	9	0.36	56
	CF	–	–	0.68	96	0.76	78	0.27	14	0.90	12	0.23	28	0.57	9	0.29	62
With dose apportionment	FOCE-I ODE	0.00	NE	0.00	NE	1.37	NE	0.31	NE	0.54	NE	0.00	NE	0.91	NE	0.00	NE
Different absorption rates	CF	0.00	NE	0.00	NE	1.42	NE	0.33	NE	0.54	NE	0.00	NE	0.86	NE	0.00	NE
	SAEM ODE	0.44	46	2.13	32	1.51	57	0.36	12	0.78	10	0.20	46	0.64	9	0.30	51
	CF	0.12	21	2.00	39	4.89	21	0.30	12	0.75	11	0.15	89	0.60	9	0.41	30
With dose apportionment	FOCE-I ODE	0.01	235	1.12	52	–	–	0.34	37	0.53	76	0.06	3579	0.91	54	0.01	117
Similar absorption rates	CF	0.01	NE	1.15	NE	–	–	0.35	NE	0.54	NE	0.05	NE	0.85	NE	0.01	NE
	SAEM ODE	0.07	34	1.66	22	–	–	0.31	12	0.10	10	0.20	36	0.54	10	0.34	43
	CF	0.07	37	1.96	22	–	–	0.29	12	0.12	12	0.14	61	0.53	9	0.49	28

RSE (%, in grey) for the four structural models and the model with similar absorption rates, encoded in ordinary differential equations (ODE) and closed form (CF) using both the FOCE-I and the SAEM algorithms implemented in NONMEM and MONOLIX respectively, on data at W4

NE not estimated, ω between-subject standard deviation

^aEstimates that rely on the assumption that V _m = V _p