Fig. 4.

Effect of SN79 on the development of sensitization to cocaine. Male, Swiss Webster mice were injected (i.p.) with either saline (Sal) or SN79 (1 or 10 mg/kg) followed 15 min later with either saline or cocaine (Coc, 10 mg/kg) once a day for 5 days. A 10-day drug-free period followed. On day 15, all of the mice were injected (i.p.) with saline, followed 15 min later with cocaine (10 mg/kg). Mice that received SN79 (1 and 10 mg/kg) on days 1–5 did not exhibit a sensitized response to cocaine on day 15. Data are represented as mean ± S.E.M., ^# p < 0.05, ^$ p < 0.05, ^$$ p < 0.01 vs. saline group (gray line), post hoc Dunnett’s tests, n = 8 per group