Fig. 5.

Effect of SN79 on the expression of sensitization due to subchronic treatment with cocaine. Male, Swiss Webster mice were injected (i.p.) with saline (Sal, gray lines) or cocaine (Coc, 10 mg/kg, black lines), once a day for 5 days. Following a 10-day drug-free period (day 15), mice were injected (i.p.) with saline (Sal) or SN79 (1, 3, 10 mg/kg), followed 15 min later with cocaine (Coc, 10 mg/kg). SN79 (3 and 10 mg/kg) treatment blocked the expression of sensitization to cocaine. Data are represented as mean ± S.E.M., **p < 0.01, ***p < 0.001 and ^## p < 0.01, ^### p < 0.001 post hoc Tukey’s tests (comparing saline + cocaine treatment with SN79 + cocaine treatment in groups treated during days 1–5 with either saline or cocaine, respectively), n = 6 per group