Fig. 8.

Effect of subchronic treatment of SN79 on motor incoordination. Male, Swiss Webster mice that were trained to balance on the rotor rod were injected (i.p.) once a day with saline or SN79 (10 mg/kg), and rotor rod performance was evaluated for five consecutive days. Subchronic SN79 treatment caused tolerance to the motor incoordination observed on day 1. The data are represented as mean ± S.E.M. A two-way ANOVA was conducted followed by Bonferroni’s post hoc tests. ^# p < 0.05, ^## p < 0.01 as compared to the saline control, n = 7 per group