Table I.
Treatment Schedule for Sensitization Experiments
| Group | Day 1–5 | Day 6–14 | Day 15 |
|---|---|---|---|
| Development of sensitization | |||
| 1 | Sal + Sal | NT | Sal + Coc |
| 2 | Sal + Coc | NT | Sal + Coc |
| 3 | SN (1 mg/kg) + Coc | NT | Sal + Coc |
| 4 | SN (10 mg/kg) + Coc | NT | Sal + Coc |
| 5 | SN (1 mg/kg) + Sal | NT | Sal + Coc |
| 6 | SN (10 mg/kg) + Sal | NT | Sal + Coc |
| Expression of sensitization | |||
| 1 | Sal + Sal | NT | Sal + Coc |
| 2 | Sal + Sal | NT | SN (1 mg/kg) + Coc |
| 3 | Sal + Sal | NT | SN (3 mg/kg) + Coc |
| 4 | Sal + Sal | NT | SN (10 mg/kg) + Coc |
| 5 | Sal + Coc | NT | Sal + Coc |
| 6 | Sal + Coc | NT | SN (1 mg/kg) + Coc |
| 7 | Sal + Coc | NT | SN (3 mg/kg) + Coc |
| 8 | Sal + Coc | NT | SN (10 mg/kg) + Coc |
All compounds were administered intraperitoneally. n = 6–8 per group
NT no treatment, Coc cocaine (10 mg/kg), Sal saline, SN SN79