Table I.
Group | Day 1–5 | Day 6–14 | Day 15 |
---|---|---|---|
Development of sensitization | |||
1 | Sal + Sal | NT | Sal + Coc |
2 | Sal + Coc | NT | Sal + Coc |
3 | SN (1 mg/kg) + Coc | NT | Sal + Coc |
4 | SN (10 mg/kg) + Coc | NT | Sal + Coc |
5 | SN (1 mg/kg) + Sal | NT | Sal + Coc |
6 | SN (10 mg/kg) + Sal | NT | Sal + Coc |
Expression of sensitization | |||
1 | Sal + Sal | NT | Sal + Coc |
2 | Sal + Sal | NT | SN (1 mg/kg) + Coc |
3 | Sal + Sal | NT | SN (3 mg/kg) + Coc |
4 | Sal + Sal | NT | SN (10 mg/kg) + Coc |
5 | Sal + Coc | NT | Sal + Coc |
6 | Sal + Coc | NT | SN (1 mg/kg) + Coc |
7 | Sal + Coc | NT | SN (3 mg/kg) + Coc |
8 | Sal + Coc | NT | SN (10 mg/kg) + Coc |
All compounds were administered intraperitoneally. n = 6–8 per group
NT no treatment, Coc cocaine (10 mg/kg), Sal saline, SN SN79