Table II.
Binding Affinities of SN79 for σ Receptors and Monoamine Transporters
| Radioligand | Nonspecific binding | Tissue | K i | |
|---|---|---|---|---|
| Sigma receptors: | ||||
| σ1 | 5 nM [3H](+)-pentazocine | 10 μM haloperidol | Rat brain | 27 ± 2 |
| σ2 | 3 nM [3H]di-o-tolylguanidine | 10 μM haloperidol | Rat brain | 7 ± 0.09 |
| Monoamine transporters: | ||||
| Dopamine | 0.5 nM [3H]WIN 35,428 | 50 μM cocaine | Rat striatum | 2,610 ± 57 |
| Serotonin | 0.2 nM [3H]paroxetine | 1.5 μM imipramine | Rat brainstem | 159 ± 15 |
| Norepinephrine | 0.5 nM [3H]nisoxetine | 4 μM desipramine | Rat cerebral cortex | 177 ± 14 |
Affinities (K i in nanomolars) were determined in the rat brain. The values in this table represent the mean ± S.E.M. from replicate assays