Table I.
Associations Between HLA Gene Polymorphisms and Humoral Immune Responses After Two Doses of MMR Vaccine
| HLA Gene | Genes and alleles (p value) | Effect on antibody level | Number of subjects | References |
|---|---|---|---|---|
| Measles vaccine | ||||
| HLA class I | B*3503 (p = 0.01) | Increased | 346 | Not published |
| HLA class II | DRB1*0701 (p = 0.03), DQA1*0201 (p = 0.03) | Decreased | 346 | Not published |
| HLA class I haplotype | A*29-C*16-B*44 (p = 0.08) | Decreased | 346 | (15) |
| HLA class II haplotype | DRB1*15/16-DQB1*06-DPB1*04 (p = 0.02) | Increased | 346 | (15) |
| HLA class II haplotype | DRB1*15/16-DQB1*06-DPB1*03 (p = 0.09) | Increased | 346 | (15) |
| Rubella vaccine | ||||
| HLA class I | A*2705 (p = 0.001), A*5701 (p = 0.03) | Decreased | 738 | (16) |
| HLA class I | A*4501 (p = 0.02) | Increased | 738 | (16) |
| HLA class II | DPA1*0201 (p = 0.005), DPB1*0301 (p = 0.01), DPB1*1301 (p = 0.04) | Decreased | 738 | (16) |
| HLA class II | DPB1*0401 (p = 0.001) | Increased | 738 | (16) |
| HLA class I haplotype | A*03-C*07-B*07 (p = 0.04) | Decreased | 738 | (16) |
| HLA class II haplotype | DRB1*04-DQB1*03-DPB1*03 (p = 0.01) | Decreased | 738 | (16) |
| HLA class II haplotype | DRB1*15/16-DQB1*06-DPB1*03 (p = 0.005) | Decreased | 738 | (16) |
| Mumps vaccine | ||||
| HLA class II | DQB1*0303 (p = 0.04) | Decreased | 346 | (18) |
| HLA class I haplotype | A*26-C*12-B*38 (p = 0.007) | Increased | 346 | (15) |
| HLA class I haplotype | A*29-C*16-B*44 (p = 0.03) | Decreased | 346 | (15) |