Figure 7.
The HDAC inhibitor RGFP136 requires CBP to enhance long-term memory of OLM. A, Mice received subthreshold training (3 min) in an environment with two identical objects immediately followed by intrahippocampal infusions of RGFP136 (1.25 ng/side) or vehicle (0.5 μl/side) and received a retention test 24 h later in which one object is moved to a new location. B, Wild-type CBP+/+ mice that received intrahippocampal RGFP136 immediately after training showed significant long-term memory for the object location compared with vehicle-treated mice. CBPKIX/KIX mice showed no effect of drug treatment (n = 5–9 per group; two-way ANOVA, **p < 0.001).