Table 1. RPTPα mutants observed in human tumour samples.

Mutant	Occurrence	Splicing error	Protein mutation	Deleted catalytic regions
RPTPα245	1/9 Breast	New cryptic exon within	Δ(238–793); +8 spurious	D1, D2
	2/8 Colon	CDS introns 5–6	COOH amino acids
	1/2 Liver
	0/7 Lung
	0/10 Thyroid
RPTPα445	0/9 Breast	Deleted CDS exons 10–12;	Δ(339–479); Δ(561–793);	D1, D2
	1/8 Colon	CDS introns 14–15 not excised	+26 spurious COOH amino acids
	0/2 Liver
	0/7 Lung
	0/10 Thyroid
RPTPα652	1/9 Breast	Deleted CDS exons 10–12	Δ(339–479)	D1
	0/8 Colon
	0/2 Liver
	0/7 Lung
	0/10 Thyroid
Exons and introns are numbered according to the wt RPTPα short isoform sequence starting with 1 at the first coding sequence exon (this is exon 4 in Vega transcript PTPRA-001 and exon 5 in PTPRA-002). Protein sequences are numbered according to the wt sequence starting with 1 at the N-terminal Met. CDS: coding sequence.