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. Author manuscript; available in PMC: 2012 Aug 15.
Published in final edited form as: Chem Res Toxicol. 2011 Jul 19;24(8):1297–1303. doi: 10.1021/tx200188j

Figure 3.

Figure 3

DNA adduct levels at 2 days, 1, 2 and 4 weeks after the last dose of DB[a,l]P treatment (24 nmol, 3 times per week, for 5 weeks) in the oral tissues (same as described at Figure 1). For (−)-anti-trans-DB[a,l]PDE-dA adduct, a significant decrease was observed after 1 week (* p < 0.05) compared with 2 days after, and was consistently decreased after 2 and 4 weeks (** p < 0.005). In addition, levels at 2 and 4 week post treatment was also significantly lower compared to the 1 week post treatment (≠p < 0.05). For (−)-anti-cis-DB[a,l]PDE-dA adduct, DNA adduct level dropped until 4 weeks after last dose (* p < 0.05) compared with 2 days after (n=3).