Table 4.
Clinical Features of the c.1477C>T (p.R493X) GRN Mutation Compared With Other GRN Mutations
| Characteristic | c.1477C>T (p.R493X) (n=18) | Other GRN Mutations (n=79) | P Valuea |
|---|---|---|---|
| Age at onset, median (IQR), y | 57.0 (50.5-61.0) | 58.5 (53.0-65.0) | .12 |
| Age at death, median (IQR), y | 64.0 (55.5-68.5) | 66.0 (61.0-73.0) | .10 |
| Disease duration, median (IQR), y | 5.0 (3.0-9.0) | 7.0 (5.0-8.0) | .89 |
| Male sex, No. (%) | 13/18 (72.2) | 35/79 (44.3) | .04 |
| Family history, No. (%) | 9/15 (60.0) | 50/63 (79.4) | .18 |
| MND, No. (%) | 0 | 9/76 (11.8) | .20 |
| PD/CBS/PSP, No. (%) | 0 | 5/77 (6.5) | .58 |
Abbreviations: CBS, corticobasal syndrome; IQR, interquartile range; MND, motor neuron disease; PD, Parkinson disease; PSP, progressive supranuclear palsy.
a
P values determined by log-rank testing for continuous variables and Fisher exact testing for categorical variables. Significant values are given in boldface type.