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. 2011 Aug 23;6(8):e22982. doi: 10.1371/journal.pone.0022982

Figure 1. Putative complexes formed by Nef Acidic Cluster with TRAF2 and TRAF6.

Figure 1

Upper panels: sequence alignment between Nef AC and TRAF2 (A) or TRAF6 (B) binding sites in known TRAF interactors. The conserved residues within the consensus sequence are in black background whereas the residues present in Nef AC as well as in TRAF2 and TRAF6 interactors are in gray background. Mismatched Ala in Nef compared to TRAF6 consensus in (B) is in gray. TRAFs interactors sequences are as in [22], [23]. Lower panels: schematic representation of the modelled complexes formed by Nef AC with TRAF2 (A) and TRAF6 (B). Nef AC-TRAF2 complex has been modelled using the three-dimensional structure of the TRAF2/4-1BB complex (PDB code: 1D0J) [22] as a template. Nef AC backbone is shown in green, TRAF2 backbone in gold. Nef AC-TRAF6 complex has been modelled using the three-dimensional structure of the TRAF6/RANK complex (PDB code 1LB5) [23]. Nef AC backbone is shown in green, TRAF6 backbone in magenta.