Figure 4. Dose-response analysis of IL-6 and TNFα mRNA.

Primary human MDMs were treated for 2 h with the indicted doses of myr⁺ wild type recNef (dark line, empty circles) or myr⁺ 4EA recNef mutant (gray line, empty squares). Cells were processed as reported in the Materials and Methods section. Upper panel: IL-6 mRNA levels; lower panel: TNFα mRNA levels. Results in figure and in Table I represent two out of four independent experiments.