Figure 4. Trypanocidal activity of NVP-BEZ235 in an acute mouse infection model.
Three independent groups (n = 5 per dose group) were infected with T. b. rhodesiense, and treated with DMSO, 5 mg/kg or 10 mg/kg of NVP-BEZ235, intraperitoneally, once a day. The arrow indicates the drug dosing schedule. The mean parasitemia for each group is represented for each day up to the death of all mice in a group. The mean survival day (MSD) is labeled in the graphic with daggers.