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BMP7 does not increase epithelial cell activation. Explants were infected with adenovirus coding for GFP alone and incubated with 15 nM BMP7 or vehicle. After 72 hours in culture, GFP-positive cells were scored as epithelial, activated, or transformed as described in “Results.” The distribution of GFP-positive cells in PE explants incubated with BMP7 was similar to the distribution of GFP-positive cells in vehicle-incubated explants.
