Table 5.
Functional enrichment analysis of differently regulateda genes with AhR enrichmentb using DAVID.
| Category | Team | Gene Count | Fold enrichment | P-value |
|---|---|---|---|---|
| Enrichment Score: 7.34 | ||||
| GOTERM_BP_3 | GO:0006629 ~ lipid metabolic process | 76 | 2.23 | 5.53E-11 |
| GOTERM_BP_3 | GO:0044255 ~ cellular lipid metabolic process | 53 | 2.23 | 7.80E-08 |
| GOTERM_BP_3 | GO:0008610 ~ lipid biosynthetic process | 32 | 2.30 | 2.28E-05 |
| Enrichment Score:4.12 | ||||
| GOTERM_BP_3 | GO:0048523 ~ negative regulation of cellular process | 94 | 1.60 | 4.46E-06 |
| GOTERM_BP_3 | GO:0048519 ~ negative regulation of biological process | 101 | 1.54 | 7.83E-06 |
| GOTERM_BP_3 | GO:0031324 ~ negative regulation of cellular metabolic process | 45 | 1.85 | 8.99E-05 |
| GOTERM_BP_3 | GO:0051172 ~ negative regulation of nitrogen compound metabolic process | 39 | 1.96 | 9.68E-05 |
| GOTERM_BP_3 | GO:0009890 ~ negative regulation of biosynthetic process | 40 | 1.86 | 2.33E-04 |
| GOTERM_BP_3 | GO:0009892 ~ negative regulation of metabolic process | 46 | 1.74 | 3.20E-04 |
| GOTERM_BP_3 | GO:0010605 ~ negative regulation of macromolecule metabolic process | 43 | 1.72 | 6.88E-04 |
| Enrichment Score: 3.54 | ||||
| GOTERM_BP_3 | GO:0009410 ~ response to xenobiotic stimulus | 8 | 10.59 | 3.54E-06 |
| GOTERM_BP_3 | GO:0006805 ~ xenobiotic metabolic process | 7 | 11.59 | 1.12E-05 |
| GOTERM_BP_3 | GO:0018894 ~ dibenzo-p-dioxin metabolic process | 3 | 19.86 | 7.31E-03 |
| GOTERM_BP_3 | GO:0009404 ~ toxin metabolic process | 3 | 11.92 | 2.28E-02 |
| Enrichment Score: 2.70 | ||||
| GOTERM_BP_3 | GO:0051272 ~ positive regulation of call motion | 9 | 4.58 | 6.00E-04 |
| GOTERM_BP_3 | GO:0051270 ~ regulation of cell motion | 15 | 2.84 | 7.55E-04 |
| GOTERM_BP_3 | GO:0040017 ~ Positive regulation of locomotion | 9 | 4.26 | 1.01E-03 |
| GOTERM_BP_3 | GO:0030334 ~ regulation of cell migration | 13 | 2.87 | 1.76E-03 |
| GOTERM_BP_3 | GO:0040012 ~ regulation of locomotion | 13 | 2.39 | 7.93E-03 |
| GOTERM_BP_3 | GO:0040012 ~ regulation of localization | 32 | 1.61 | 9.36E-03 |
| Enrichment Score: 2.55 | ||||
| GOTERM_BP_3 | GO:0048518 ~ positive regulation of biological process | 106 | 1.44 | 7.45E-05 |
| GOTERM_BP_3 | GO:0048522 ~ positive regulation of cellular process | 94 | 1.45 | 2.03E-04 |
| GOTERM_BP_3 | GO:0009893 ~ positive regulation of metabolic process | 51 | 1.53 | 2.64E-03 |
| GOTERM_BP_3 | GO:0010604 ~ positive regulation of macromolecule metabolic process | 48 | 1.54 | 3.02E-03 |
| GOTERM_BP_3 | GO:0031325 ~ positive regulation of cellular | 47 | 1.48 | 6.67E-03 |
| GOTERM_BP_3 | GO:0009891 ~ positive regulation of biosynthetic | 38 | 1.38 | 3.96E-02 |
| GOTERM_BP_3 | GO:0031325 ~ positive regulation of nitrogen compound metabolic process | 36 | 1.39 | 4.40E-02 |
| Enrichment Score: 2.44 | ||||
| GOTERM_BP_3 | GO:0005996 ~ monosaccharide metabolic process | 21 | 2.27 | 9.50E-04 |
| GOTERM_BP_3 | GO:0005975 ~ carbohydrate metabolic process | 37 | 1.67 | 2.63E-03 |
| GOTERM_BP_3 | GO:0016051 ~ carbohydrate biosynthetic process | 11 | 2.70 | 7.19E-03 |
| GOTERM_BP_3 | GO:0044262 ~ cellular carbohydrate metabolic process | 27 | 1.70 | 9.34E-03 |
a |fold-change| ≥ 1.5 and P1(t) >0.999 at one or more time points
b AhR enriched regions at 2 hrs with FDR < 0.01