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. Author manuscript; available in PMC: 2011 Dec 30.
Published in final edited form as: Nature. 2011 May 29;474(7353):662–665. doi: 10.1038/nature10099

Figure 1.

Figure 1

Structures of Native and Misfolded I27 Constructs. (a) Natively folded I27-I27 tandem repeat with labelling positions highlighted (golden spheres). (b) Native I27 crystal structure (1tit.pdb) with labelling positions corresponding to those expected for the misfolded state of I27-I27. (c) One of the domain-swapped misfolded state structures formed in Gō-model simulations. (d) Schematic of this misfolded state topology: hydrogen bonds that are perpendicular to the direction of applied force in AFM mechanical unfolding are shown by dashed lines (circled). Four other misfolded state topologies were populated in the simulations (Supplementary Fig. 5b). We note that we cannot distinguish between such topologies from the results presented here.