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. Author manuscript; available in PMC: 2012 Mar 1.
Published in final edited form as: J Immunol. 2011 Aug 3;187(5):2602–2616. doi: 10.4049/jimmunol.1101004

Figure 3. The effect of an adenoviral prime is consistent in other mouse strains and with other antigens.

Figure 3

BALB/c mice (n=5 / group) were immunized twice i.m. three weeks apart with a mixture of 10μg of P. falciparum EBA-175 protein and 10μg of P. falciparum MSP-119 protein. IgG titers were measured in the serum to (A) EBA-175 protein two weeks after each immunization (Imx). Median responses are shown with range. IgG titers were measured in the serum in response to (B) EBA-175 protein and (C) MSP-119(QKNG allele) protein two weeks after the final immunization. Median responses are shown. BALB/c mice were primed i.m. with a mixture of 1×109 vp of AdHu5-MSP-1and AdHu5-EBA-175 and boosted i.m. eight weeks later with a mixture of 10μg of P. falciparum EBA-175 protein and 10μg of P. falciparum MSP-119 protein. IgG titers were measured in the serum in response to (D) EBA-175 protein and (E) MSP-119 (QKNG) protein eight weeks after the prime (Inline graphicpre-boost) and two weeks after the protein vaccine boost (Inline graphicpost-boost). Median responses are shown with range. * p<0.05by one-way ANOVA with Bonferroni’s multiple comparison post-test. ***p<0.001 by two-way ANOVAwith Bonferroni’s multiple comparison post-test.