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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Biometrics. 2011 Jan 6;67(3):1092–1099. doi: 10.1111/j.1541-0420.2010.01539.x

Table 1.

Multinomial probabilities describing reader error associated with determining time of progression. Observed event times are shifted according to these probabilities. Local evaluations follow the probabilities described here, while the BICR follow the first row (see text).

Amount of Differential Reader Bias Multinomial Probabilities
Control Treatment Experimental Treatment
p−3 p−2 p−1 p0 p1 p2 p−3 p−2 p−1 p0 p1 p2
None 0.025 0.025 0.1 0.7 0.1 0.05 0.025 0.025 0.1 0.7 0.1 0.05
Small 0.05 0.15 0.3 0.4 0.05 0.05 0.025 0.025 0.1 0.7 0.1 0.05
Large 0.1 0.2 0.4 0.2 0.05 0.05 0.025 0.025 0.1 0.7 0.1 0.05