Table 1.
Multinomial probabilities describing reader error associated with determining time of progression. Observed event times are shifted according to these probabilities. Local evaluations follow the probabilities described here, while the BICR follow the first row (see text).
Amount of Differential Reader Bias | Multinomial Probabilities | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Control Treatment | Experimental Treatment | |||||||||||
p−3 | p−2 | p−1 | p0 | p1 | p2 | p−3 | p−2 | p−1 | p0 | p1 | p2 | |
None | 0.025 | 0.025 | 0.1 | 0.7 | 0.1 | 0.05 | 0.025 | 0.025 | 0.1 | 0.7 | 0.1 | 0.05 |
Small | 0.05 | 0.15 | 0.3 | 0.4 | 0.05 | 0.05 | 0.025 | 0.025 | 0.1 | 0.7 | 0.1 | 0.05 |
Large | 0.1 | 0.2 | 0.4 | 0.2 | 0.05 | 0.05 | 0.025 | 0.025 | 0.1 | 0.7 | 0.1 | 0.05 |