Figure 8.

The rocF mutant of Helicobacter pylori colonizes arginase II knockout mice treated with the arginase inhibitor S-(2-boronoethyl)-L-cysteine. Arginase II knockout mice (n = 3 or 4 per group) were orally fed water or S-(2-boronoethyl)-L-cysteine (BEC) (50 mmol/L) once or twice daily for 3 d before oral inoculation with wild-type or rocF mutant Helicobacter pylori strain SS1 (~108 CFU). The BEC animal groups continued to receive BEC daily until animals were euthanized. At 1 wk post-infection, animals were euthanized and the stomach dissected into antrum (A), body (B), or fundus (C). Limit of detection: ~100 CFU/g tissue. Bar, mean CFU/g stomach.