Fig. 1.

Paclitaxel plasma concentration versus time curves after oral administration of different SMEOF (SMEOF#1–SMEOF#4, 1.5% w/w paclitaxel) formulations and Taxol® or i.v. administration of paclitaxel in a Polysorbate 80: ethanol solution in wild-type with or without co-administration of Cyclosporin A (10 mg/kg). Plasma levels of paclitaxel were determined by a validated HPLC method with lower limit of quantification (25 ng/mL). Data points are expressed as mean concentrations for oral and i.v. (n = 5) administration; error bars indicate Standard Errors (SEs)