Fig. 3.

Fecal excretion of paclitaxel in P-gp knockout and Wild-type mice co-administered with CsA (10 mg/kg). The mice were housed in metabolic cages and were treated with an oral administration of SMEOF#3 (with 1.5% w/w or 3.0% w/w paclitaxel) at different doses of 10, 30, or 60 mg/kg. Paclitaxel levels were measured in feces excreted between 0–96 h using a validated HPLC method. Results are expressed as percentage of the given dose; Bars ± SE (n = 5)