Table 3.
Association between genetic polymorphisms and danusertib clearance
| Gene | Polymorphism | Genotype | No. Patients | Clearance L/hour/m2 d1c1 | |
|---|---|---|---|---|---|
| Mean | SD | ||||
| ABCB1 | 1236C > T | CC | 16 | 17.8 | 6.5 |
| CT | 21 | 18.3 | 5.9 | ||
| TT | 10 | 18.6 | 4.9 | ||
| P-value | 0.930 | ||||
| 2677G > A/T | GG | 17 | 18.2 | 6.6 | |
| GT | 20 | 18.5 | 5.8 | ||
| TT | 10 | 17.7 | 4.9 | ||
| P-value | 0.948 | ||||
| 3435C > T | CC | 13 | 19.5 | 6.1 | |
| CT | 21 | 17.7 | 5.9 | ||
| TT | 13 | 17.8 | 5.6 | ||
| P-value | 0.638 | ||||
| ABCG2 | 421C > A | CC | 36 | 18.1 | 6.1 |
| CA | 11 | 18.8 | 4.8 | ||
| P-value | 0.621 | ||||
| 346G > A | GG | 45 | 18.2 | 5.9 | |
| GA | 2 | 18.6 | 5.2 | ||
| P-value | 0.755 | ||||
| 143C > T | CC | 29 | 18.9 | 6.1 | |
| CT | 15 | 17.3 | 5.5 | ||
| TT | 3 | 16. | 3.6 | ||
| P-value | 0.537 | ||||
| 15994G > A | GG | 23 | 18.5 | 5.0 | |
| GA | 21 | 18.2 | 6.2 | ||
| AA | 3 | 16.5 | 3.6 | ||
| P-value | 0.859 | ||||
| FMO3 | 15167G > A | GG | 15 | 19.5 | 6.6 |
| GA | 20 | 18.1 | 6.0 | ||
| AA | 12 | 16.9 | 4.2 | ||
| P-value | 0.537 | ||||
| 21443A > G | AA | 27 | 19.2 | 6.3 | |
| AG | 18 | 16.9 | 5.1 | ||
| GG | 2 | 16.4 | 1.3 | ||
| P-value | 0.382 | ||||
| 18281G > A | GG | 35 | 18.1 | 5.2 | |
| GA | 11 | 17.2 | 6.1 | ||
| AA | 1 | 34.0 | n.a. | ||
| P-value | 0.017 | ||||
n.a: not applicable