Table 4.
Association between genetic polymorphisms and grade 3–4 neutropenia in cycle 1 in all patients at RP2D levels
| Neutropenia grade 3–4 | p-value | |||||
|---|---|---|---|---|---|---|
| Gene | Polymorphism | Genotype | Total No. Patients | No | Yes | wt/wt vs wt/m vs m/m |
| KDR | −604T > C | TT | 6 | 3 | 3 | 0.308 |
| TC | 15 | 7 | 8 | |||
| CC | 9 | 7 | 2 | |||
| 1192G > A | GG | 27 | 15 | 12 | 1.000 | |
| GA | 3 | 2 | 1 | |||
| 1719A > T | AA | 1 | 0 | 1 | 0.426 | |
| AT | 15 | 8 | 7 | |||
| TT | 14 | 9 | 5 | |||
| 54G > A | GG | 9 | 5 | 4 | 0.673 | |
| GA | 16 | 10 | 6 | |||
| AA | 5 | 2 | 3 | |||
| −92G > A | AA | 3 | 3 | 0 | 0.265 | |
| AG | 7 | 4 | 3 | |||
| GG | 20 | 10 | 10 | |||
| RET | 37412G > A | GG | 24 | 14 | 10 | 0.507 |
| GA | 5 | 2 | 3 | |||
| AA | 1 | 1 | 0 | |||
| 135G > A | GG | 16 | 9 | 7 | 0.489 | |
| 3 missing | GA | 8 | 6 | 2 | ||
| AA | 3 | 1 | 2 | |||
| FLT3 | 738C > T | CC | 5 | 4 | 1 | 0.414 |
| CT | 15 | 7 | 8 | |||
| TT | 10 | 6 | 4 | |||
| FLT4 | 1480A > G | AA | 23 | 12 | 11 | |
| AG | 7 | 5 | 2 | |||
| AURKB | 893G > A | GG | 22 | 11 | 11 | 0.407 |
| GA | 8 | 6 | 2 | |||
| AURKA | 169G > A | GG | 18 | 10 | 8 | 0.672 |
| GA | 11 | 6 | 5 | |||
| AA | 1 | 1 | 0 | |||
| 91A > T | AA | 20 | 11 | 9 | 0.110 | |
| AT | 6 | 2 | 4 | |||
| TT | 4 | 4 | 0 | |||