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. 2011 Aug 22;194(4):551–565. doi: 10.1083/jcb.201010090

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© 2011 Tao et al.

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Figure 8. — Set7 morpholino-treated zebrafish exhibit impaired sarcomerogenesis and morphological defects in skeletal muscle. Transmission electron microscopy examinations of control or Set7 morphant skeletal muscle. (A) Set7 MO treatment results in morphologically altered myocytes with fewer and shorter myofibrils as compared with control. Bars, 10 µm. (B) Higher magnification reveals periodic absent z lines (arrow) and noticeably narrower sarcomeres as compared with control. An increased frequency of A-band branching (arrow) is observed with morpholino treatment. Bars, 500 nm. Images are representative of dorsal skeletal myocytes from n = 3 fish for both control and Set7 morphants.