Table 4.

Frequency of Delivery Outcomes by Maternal Antiviral Treatment

Characteristic	Antiviral treatment within 2 days of symptom onset (n=170)	Antiviral treatment after 2 days of symptom onset (n=107)	No antiviral treatment (n=37)	Antiviral treatment (vs. none)		Antiviral treatment within 2 days of symptom onset (vs. none or not within 2 days)
				Unadjusted Odds Ratio (95% CI)	Adjusted Odds Ratio* (95% CI)	Unadjusted Odds Ratio (95% CI)	Adjusted Odds Ratio* (95% CI)
Cesarean delivery	53 (31.2)	43 (40.2)	13 (35.1)	0.97 (0.48–2.00) p=0.94	0.99 (0.46–2.14) p=0.98	0.71 (0.45–1.14) p=0.15	0.77 (0.47–1.26) p=0.29
Neonatal morbidity/mortality composite	51 (30.0)	34 (31.8)	14 (37.8)	0.74 (0.36–1.50) p=0.40	0.61 (0.27–1.35) p=0.22	0.86 (0.53–1.38) p=0.53	0.92 (0.54–1.56) p=0.76
Fetal death	2 (1.2)	3 (2.8)	0 (0.0)
Neonatal death	0 (0.0)	2 (1.9)	0 (0.0)
Pre-term birth	27 (15.9)	21 (19.6)	11 (29.7)
Spontaneous†‡	11 (6.5)	7 (6.7)	3 (8.1)
Indicated‡	15 (8.9)	12 (11.4)	8 (21.6)
NICU admission	32 (18.8)	21 (19.6)	10 (27.0)
RDS	11 (6.5)	4 (3.7)	3 (8.1)
NEC	0 (0.0)	1 (0.9)	0 (0.0)
Neonatal sepsis	0 (0.0)	1 (0.9)	1 (2.7)
Major congenital malformations	0 (0.0)	2 (1.9)	2 (5.4)

Data are n (%), unless otherwise specified.

NICU = neonatal intensive care unit; RDS = respiratory distress syndrome; NEC = necrotizing enterocolitis.

^*Adjusted for baseline maternal age, smoking, asthma, anemia, chronic hypertension, diabetes, medication allergy and maternal ICU admission during the index ILI hospitalization.

^†Spontaneous pre-term birth defined as delivery before 37 weeks with spontaneous or spontaneous augmented labor or preterm premature rupture of membranes (pPROM).

^‡Three pre-term birth cases were not classified as spontaneous or indicted due to missing data regarding type of labor and/or PROM.