Figure 1.

Representative histological patterns of lesions in the formalin-fixed paraffin-embedded whole mount radical prostatectomy specimens (H&E staining) from patients with prostate cancer. A. area of benign prostate tissue; B – area of prostate adenocarcinoma; C. benign tissue adjacent to an area of adenocarcinoma; D. site of mononuclear cells (MNC) accumulation (“hot spot”) in benign prostate tissue is comprised of cells with the morphologic features of lymphocytes; E. proliferative inflammatory atrophy (PIA) lesion in benign prostate tissue. Black arrowheads (x800) indicate intraluminal cells with monocyte/macrophage morphology and white arrowhead (x800) indicate intraluminal cell with neutrophil morphology. Scattered cells (red arrow, ×800) with lymphocyte morphology (similar to D, ×800) are shown in peri-glandular stroma of PIA lesion. Left column presents prostate histologic zones at magnification ×125. Right column illustrates tissue located inside of the black squares of the left column in the same samples at magnification ×800. Details are described in “Materials and Methods” section.