Figure 3.

Leukocyte sequestration in brain microvessels and its relation to edema during PbA infection. A. Individual microvessels were analysed in 15 mice per group. 518 and 398 vessels were studied in CBA and BALB/c mice, respectively. Mann-Whitney test. B. Proportion of microvessels containing more than 2 WBC. Each dot represents percentages in individual mice (n = 15). Representative post-capillary venule with 10, 5, or 3 leukocytes, (C, D, E, respectively). PbA-infected CBA mouse, day 7 p.i. Haematoxylin-eosin staining, magnification 400×. F. Intravascular leukocyte numbers correlate with PVS and AQP4 (same vessels studied as in A.). Non parametric Mann-Whitney U test.