Table 1.
Patient information. Correlations between mutations and clinical and histopathologic parameters of IPMNs.
N (total) |
KRAS mutation
|
P |
GNAS mutation
|
P | ||||
---|---|---|---|---|---|---|---|---|
n | % | n | % | |||||
Age (years) | <65 | 29 | 22 | 75.9 | 0.42 | 18 | 62.1 | 0.62 |
≥65 | 103 | 85 | 82.5 | 69 | 67 | |||
Gender | Male | 70 | 58 | 82.9 | 0.58 | 51 | 72.9 | 0.07 |
Female | 62 | 49 | 79 | 36 | 58.1 | |||
History of smoking | Yes | 25 | 21 | 84 | 0.77 | 17 | 68 | 0.85 |
No | 37 | 30 | 81.1 | 26 | 70.3 | |||
Grade | Low | 23 | 20 | 87 | 0.43 (low versus others) | 11 | 47.8 | 0.04 (low versus others) |
Intermediate | 51 | 46 | 90.2 | 34 | 66.7 | |||
High | 58 | 41 | 70.7 | 42 | 72.4 | |||
Duct type | Main | 35 | 23 | 65.7 | 0.002 (main versus branch) | 24 | 68.6 | 0.37 (main versus branch) |
Branch | 64 | 58 | 90.6 | 38 | 59.4 | |||
Mixed | 28 | 21 | 75 | 20 | 71.4 | |||
Subtype | Gastric | 52 | 45 | 86.5 | 0.02 (pancreatobiliary versus intestinal) | 34 | 65.4 | 0.002 (pancreatobiliary versus intestinal) |
Pancreatobiliary | 7 | 7 | 100 | 3 | 42.9 | |||
Intestinal | 13 | 6 | 46.2 | 13 | 100 | |||
Diameter (cm) | <3 | 62 | 49 | 79 | 0.58 | 41 | 66.1 | 0.96 |
≥3 | 70 | 58 | 82.9 | 46 | 65.7 | |||
Location | Proximal (head) | 77 | 64 | 83.1 | 0.44 (proximal versus distal) | 53 | 68.8 | 0.38 (proximal versus distal) |
Distal (body, tail) | 49 | 38 | 77.6 | 30 | 61.2 | |||
Proximal and distal | 6 | 5 | 83.3 | 4 | 66.7 | |||
Associated cancer | Yes | 24 | 18 | 75 | 0.4 | 18 | 75 | 0.3 |
No | 108 | 89 | 82.4 | 69 | 63.9 |