Table 2B.

Differences in salivary cortisol concentrations between paired time points, delta cortisol (nmol/L)

Group	Sex (n)	Day 1					Day 2
		8 am		1 pm	8 pm		8 am	Delta 8 am–1 pm	Delta 1 pm–8 pm	Delta 8 am–8 pm
		Geom mean median with (10th and 90th perc)	P-valueb	Geom mean median with (10th and 90th perc)	Geom mean median with (10th and 90th perc)	P-valueb	Geom mean median with (10th and 90th perc)	Geom mean median	Geom mean median	Geom mean median	P-valueb
PD-P	Male (16)	12.5		5.6	2.3		15.1	6.9	3.3	10.2
		14.8 (5.2–20.3)	0.215	5.6 (3.2–11.8)	2.6 (1.1–5.1)	0.016c	14.2 (5.1–35)	9.2	3.0	12.2	0.049c
	Female (27)	15.6		6.4	3.4		15.1	9.2	3.0	12.2
		17.9 (5.8–30)	0.021c	6.2 (2.6–21.2)	2.9 (1.6–8.5)	0.614	15.4 (7.6–28.6)	11.7	3.3	15.0	0.052
PD no-P	Male (8)	20.5		6.4	4.2		16.9	14.1	2.2	16.3
		15.4 (5.7–174.6)	0.128	6.5 (2.1–22.3)	3.1 (2.2–14.6)	0.779	12.9 (4.6–110)	8.9	3.4	12.3	0.128
	Female (8)	17.5		5.3	2.8		13.0	12.2	2.5	14.7
		16.8 (7.8–38.2)	0.091	5.6 (3.5–8.0)	2.6 (2–5.5)	0.035c	12.1 (7.6–23.2)	11.2	3	14.2	0.043c
Reference	Male (303)	12.1a	–	–	3.9b	–	–	–	–	8.2a	–
	Female (305)	12.5a	–	–	4.1b	–	–	–	–	8.4a	–

Notes:

^aValues are given as geometric mean;

^btesting median of the corresponding reference population;

^cstatiscally singinificant at 5% level.

Abbreviations: Geom, geometric; perc, percentiles; PD, Parkinson’s disease; PD no-P, PD without pain; PD-P, PD with pain.