Table 2. Composition of putative excreted/secreted proteins inferred from the transcriptome of adult Trichuris suis and corresponding (conserved) signature protein motifs.
| Predicted proteins | Number (%) | Pfam domain(s) (code)/number of putative peptides |
| Proteases | 281 (21.8) | |
| Serine proteases* | 42 | Serine carboxypeptidase (PF05577.5); |
| 29 | Rhomboid serine protease (PF12595.1); | |
| 27 | Serine proteinase (PF01972.9) | |
| Metalloproteases | 38 | Zinc metalloprotease (PF01421.12); |
| 22 | Metallopeptidase family (PF00557.17); | |
| 18 | Aminopeptidase I zinc metalloprotease (PF02127.8) | |
| Cysteine proteinase | 32 | Cysteine protease (PF00548.13) |
| 12 | Calpain family cystein protease (PF00648.14) | |
| Aspartyl proteases | 6 | Eukaryotic aspartyl protease (PF00026.16); |
| 4 | Aspartyl protease (PF09668.3); | |
| 2 | Retroviral aspartyl protease (PF00077.13) | |
| Other peptidases | 41 | Peptidase family (PF03416.12; PF01431.14; PF01435.11); |
| 8 | Trypsin (PF00089.19) | |
| Uncharacterised proteins | 200 (15.5) | |
| 161 | Uncharacterised protein families (PF03665.6; PF03650.6)/161; | |
| 39 | Uncharacterised, conserved proteins (PF09758.2; PF10103.2; PF10171.2; PF10217.2; PF10225.2; PF10229.2; PF10164.2; PF10226.2) | |
| Protein kinases | 143 (11.1) | |
| Hexokinases | 27 | Hexokinase (PF00349.14) |
| Serine/threonine kinases | 17 | Serine/threonine protein kinase (PF05445.4) |
| Acylglycerol-kinases | 9 | Dyacylglycerol kinase (PF00609.12; PF00781.17) |
| Other kinases | 24 | Adenylate kinase (PF00406.15); |
| 19 | Protein kinase domain (PF00069.18); | |
| 19 | Phosphofructokinase (PF00365.13); | |
| 16 | Pyruvate kinase (PF02887.9); | |
| 5 | Calcium-calmodulin dependent protein kinase (PF08332.3); | |
| 5 | Fructosamine kinase (PF03881.7); | |
| 2 | Deoxynucleoside kinase (PF01712.12) | |
| Receptor and channels | 139 (10.8) | |
| Lipid receptors | 7 | Low-density lipoprotein receptor (PF00057.11; PF00058.10) |
| Other receptors | 41 | A-macroglobulin receptor (PF07677.7); |
| 30 | B cell receptor associated (PF05529.5); | |
| 22 | Transient receptor ion channel (PF08344.4); | |
| 13 | Ephrin receptor ligand binding (PF01404.12); | |
| 11 | Inositol triphosphate/ryanodine receptor (PF08709.4); | |
| 8 | G protein-coupled receptor (PF12205.1); | |
| 3 | Natural killer receptor (PF11465.1) | |
| Hypothetical proteins | 143 (11.1) | |
| 133 | Conserved hypothetical protein (PF03602.8); | |
| 8 | Conserved hypothetical ATP-binding protein (PF03029.10); | |
| 2 | Hypothetical methyltransferase (PF05148.8) | |
| Transcription factors | 132 (10.2) | |
| 60 | Transcription elongation factor (PF05129.6); | |
| 51 | Transcription factor (PF01096.11; PF00382.12; PF00352.14) | |
| 21 | CP2 transcription factor (PF04516.8) | |
| Protease inhibitors | 86 (6.7) | |
| Kunitz-type protease inhibitors | 45 | Kunitz-type protease inhibitor domain (PF00014.16) |
| Serine-protease inhibitors | 11 | Serine protease inhibitor domain (PF00050.14); |
| 2 | Serpin (PF00079.13) | |
| Other protease inhibitors | 28 | Cathepsin inhibitor domain (PF08246.5) |
| Pore-forming proteins | 18 (1.4) | Eukaryotic porin (PF01459.15) |
| Other enzymes | 146 (11.3) | |
| 102 | Helicase conserved domain (PF00271.24); | |
| 39 | ATPase family (PF00004.22); | |
| 5 | Macrophage migration inhibitory factor (PF01187.11) |
*Including n = 5 serine proteases with identity (92%) to known ‘secretory leukocyte protease inhibitors’ from Mus musculus.