Table 2.
Patients' Characteristics of 48 patients with preexisting pulmonary fibrosis
| Characteristics | Total | EGFR-TKIs induced ILD (+) | EGFR-TKIs induced ILD (-) | p-value |
|---|---|---|---|---|
| Total | 48 | 8 | 40 | |
| Age (years) | ||||
| Mean (± SEM) | 67.5(± 3.6) | 66.2(± 1.8) | ||
| < 60 | 12 | 2 | 10 | 1.000 |
| ≥ 60 | 36 | 6 | 30 | |
| Sex | ||||
| Female | 11 | 3 | 8 | 0.361 |
| Male | 37 | 5 | 32 | |
| Histologic type | ||||
| Adenocarcinoma | 37 | 5 | 32 | 0.361 |
| Squamous cell carcinoma/Others | 11 | 3 | 8 | |
| Smoking history | ||||
| Current/Former | 40 | 5 | 35 | 0.116 |
| Never | 8 | 3 | 5 | |
| Disease stage | ||||
| IV | 24 | 3 | 21 | 0.701 |
| I-IIIB/Recurrence after surgery | 11 | 5 | 19 | |
| Performance status | ||||
| ≥ 2 | 26 | 5 | 21 | 0.710 |
| 0-1 | 22 | 3 | 19 | |
| No. of prior chemotherapy regimens | ||||
| ≥ 2 | 20 | 1 | 19 | 0.116 |
| 0-1 | 28 | 7 | 21 | |
| Prior thoracic radiotherapy | ||||
| Yes | 10 | 0 | 10 | 0.177 |
| No | 38 | 8 | 30 | |
| Pattern of preexisting pulmonary fibrosis | ||||
| IPF pattern | 3 | 1 | 2 | 0.429 |
| Non-IPF pattern | 45 | 7 | 38 | |
| Preexisting pulmonary emphysema | ||||
| Yes | 24 | 3 | 21 | 0.701 |
| No | 24 | 5 | 19 | |
| EGFR mutation status | ||||
| Wild type | 9 | 5 | 4 | 0.0498* |
| Mutant | 11 | 1 | 10 | |
| (Not evaluated) | (28) | (2) | (26) | |
| Types of EGFR-TKI | ||||
| Gefitinib | 40 | 5 | 35 | 0.116 |
| Erlotinib | 8 | 3 | 5 |
*p < 0.05 (Fisher's exact test)