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. Author manuscript; available in PMC: 2011 Aug 24.
Published in final edited form as: Dev Biol. 2009 Oct 20;337(1):99–109. doi: 10.1016/j.ydbio.2009.10.014

Fig. 5. Overexpression of Gprk2 or the β-arrestin Krz decreases Smo accumulation.

Fig. 5

(A,B) Wing discs with Gprk2 (blue channel in A) expressed throughout the dorsal compartment under the control of ap-GAL4. Smo (red channel in A) accumulation is reduced in dorsal-posterior cells (arrowhead). Target gene expression in Hh-responding dorsal-anterior cells, reflected by levels of Ptc (green channel in A) and Col (B), was unaffected. (C,D) Wing discs with HA-tagged Krz expressed throughout the dorsal compartment under the control of ap-GAL4. Smo (red channel in C) accumulation is reduced in dorsal-posterior cells (arrowhead). Target gene expression in Hh-responding dorsal-anterior cells, reflected by levels of Col (green channel in C) and Ptc (D), was unaffected.