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. 2011 Aug 24;6(8):e23849. doi: 10.1371/journal.pone.0023849

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A. The system and strategy to study gene expression profile, its clinical significance and functional role during NSCLC carcinogenesis and chemotherapeutic resistance. B. Classification of 1,688 regulated genes among BEAS-2B (B), NNK-BEAS-2B (NB) and H157 (H) compared to NHBE (N). Genes whose expression level did not change between cell lines were excluded. The ratios graphically visualized by Cluster and TreeView programs (http://rana.lbl.gov/EisenSoftware.htm). Pairs of lanes and reciprocal red and green colors indicate dye swapping. C. Gene expression dynamics during immortalization and/or transformation. The graphs were generated by Cluster Analysis of Gene Expression Dynamics program (http://www.genomethods.org/caged). A, C, J and H symbols depict groups of genes identified in Figure 1B.