Skip to main content
. 2011 Aug 24;6(8):e24064. doi: 10.1371/journal.pone.0024064

Figure 6. Effects of C-KIT and Mitf on cell proliferation.

Figure 6

HEK293T cells transfected with either c-KIT or Mitf did not influence the level of cell proliferation regardless of SCF stimulation. However, when wt c-KIT or c-KIT Y703F/Y936F and Mitf were introduced, SCF treatment for 48 hours resulted in an increase in cell numbers. While the c-KIT mutants Y568F and Y721F were able to mediate a proliferative response to SCF stimulation, the level of increase was significantly (p<0.01) lower compared to wt c-KIT or c-KIT Y703F/Y936F. Each bar represents the average of nine independent experiments. Error bars signify 95% confidence interval.