Table 1. Summary of morphological, self-renewal and vasculogenic properties of cardiac progenitor cell clones.
Clone | Morphology | Last Passage # | Lineage differentiation | Vasculogenic index | SDF-1 Levels pg/ml | ||
Cardiac | Smooth muscle | Endo-thelial | |||||
CL1D | small/round | 48 | − | + | + | 17.80 | 19.09 |
CL3 | flat/spindle | 23 | + | + | + | 9.11 | 12.85 |
CL6 | small/round | 10 | + | + | + | ND | ND |
CL7 | flat/spindle | 49 | + | − | + | ND | ND |
CL11B | stellate | 60 | + | + | + | 23.96 | 157.82 |
CL13 | flat/spindle | 38 | + | − | + | 14.50 | 59.40 |
CL17 | stellate | 15 | + | + | + | 21.92 | 131.57 |
CL19 | small/round | 17 | + | + | + | ND | ND |
CL20 | small/round | 15 | + | + | + | 5.90 | 29.96 |
CL20B | small/round | 50 | + | + | + | 7.91 | 37.50 |
CL22 | stellate | 15 | + | + | + | 19.40 | 202.61 |
CL23 | small/round | 15 | + | + | + | 18.19 | 54.12 |
CL25 | stellate | 11 | + | + | + | ND | ND |
CL27 | flat/spindle | 14 | + | + | + | ND | ND |
CL30C1 | flat | 54 | + | + | + | 1.97 | 15.82 |
CL32 | small/round | 15 | + | + | + | 16.80 | 45.06 |
CL42A1 | stellate | 41 | + | + | + | 9.82 | 84.91 |
Morphology was assessed by light microscopy and immunocytology. Last passage number: maximum number of passages to date. Vasculogenic index: length x number of tubes formed per high power field in Matrigel at 5 hours. SDF-1 levels were determined by ELISA (see Methods).