Table 2.
OR Model 1 (95% CI) | p value | ORs Model 2 (95% CI) | p value | ORs Model 3 (95% CI) | p value | ORs Model 4 (95% CI) | p value | |
---|---|---|---|---|---|---|---|---|
Pretreatment major resistance mutations | 2.55 (1.20, 5.42) | 0.015 | 2.16 (0.98, 4.76) | 0.055 | 1.95 (0.86, 4.42) | 0.107 | 1.29 (0.54, 3.12) | 0.566 |
Age in months at treatment initiation | — | — | 0.95 (0.88, 1.03) | 0.198 | 0.98 (0.90, 1.05) | 0.504 | 0.94 (0.87, 1.02) | 0.136 |
Pretreatment HIV-1 plasma RNA (copies/ml) ≥750K | — | — | — | — | 8.46 (1.94, 36.9) | 0.004 | 5.75 (1.26, 26.2) | 0.024 |
Pretreatment CD4+ cell count (cells/μl) <500 | 2.99 (1.28, 6.99) | 0.011 | ||||||
Pretreatment weight For age z-score | 0.716 (0.55, 0.93) | 0.012 |
Model 1 is unadjusted; Model 2 is adjusted for age at time of treatment initiation; Model 3 is adjusted for age and pretreatment plasma HIV-1 RNA level; and Model 4 is adjusted for age, pretreatment plasma HIV-1 RNA level, pretreatment CD4+ cell count, and pretreatment weight-for-age z-score. OR, odds ratio; K=1000.