Figure 5.
Schematic drawing showing glia-LHRH neuronal association and sites of ALC effects on RPTPβ in the median eminence of juvenile female rats. For clarity, details of other downstream pathways in this region are not shown. IGF-1, insulin-like growth factor-1; EGF, epidermal growth factor; ALC, alcohol, IGFR, Insulin-like growth factor receptor; PGE2, prostaglandin-E2; LHRH, luteinizing hormone releasing hormone; RPTPβ, receptor protein tyrosine phosphatase β; Caspr1, contactin associated protein-1; ER, estrogen receptor; TGF, transforming growth factor; BBB, blood brain barrier