Table 1.
Baseline characteristics of infants with no esophageal temperatures < 32.0°C compared to those with decreases < 32°C during induction or maintenance phase of cooling
| No temp <32 °C (N=58) | Temp. < 32°C during induction (N=33) | Temp. < 32°C during maintenance (N=10) | Any differences between groups (P value) | |
|---|---|---|---|---|
| Outborn, n (%) | 27 (47) | 16 (48) | 4 (40) | 0.92 |
| Male gender, n (%) | 27 (47) | 21(64) | 3 (30) | 0.12 |
| 10 minute Apgar ≤ 5 *, n (%) | 47 (85) | 23 (79) | 9 (90) | 0.70 |
| Seizures at randomization, n (%) | 23 (40) | 16 (48) | 4 (40) | 0.69 |
| Severe level of initial HIE †, n (%) Moderate level of initial HIE, n (%) |
16 (28) 41 (72) |
12 (36) 21 (64) |
3 (30) 7 (70) |
0.70 |
| Inotropic support at randomization, n (%) | 16 (28) | 11 (33) | 6 (60) | 0.12 |
| Below 25th percentile for weight at birth, n (%) | 15 (26) | 16 (48) | 6 (60) | 0.03 |
| Anti-convulsants, n (%) ‡ | 39 (70) | 24 (73) | 8 (80) | 0.85 |
| Analgesics, n (%) ‡ | 20 (37) | 15 (45) | 5 (56) | 0.53 |
| Neuromuscular blocking agents, n (%) ‡ | 8 (15) | 7 (21) | 1 (11) | 0.71 |
| Age at randomization, hrs (mean ± SD) | 4.2 ± 1.3 | 4.5 ± 1.2 | 4.1 ± 1.3 | 0.48 |
| Cord pH (mean ± SD) | 6.87 ± 0.21 | 6.86 ± 0.15 | 6.87 ± 0.15 | 0.89 |
| Cord base deficit mmol/liter (mean ± SD) | 18.5 ± 8.0 | 18.2 ± 4.6 | 19.3 ± 4.8 | 0.87 |
| Birth weight g (mean ± SD) | 3555 ± 673 | 3172 ± 450 | 3109 ± 500 | 0.005 |
*
7 infants are missing this data (3 in the first group and 4 in the second group).
†
1 infant is missing initial HIE in the first group.
‡
At any time within 72 hours study period. Infants missing this data: 2 for anti-convulsants (both in first group); 5 for analgesics (4 in the first and 1 in the third group); 7 for neuromuscular blocking agents (6 in the first and 1 in the third group).