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. Author manuscript; available in PMC: 2012 Sep 1.
Published in final edited form as: Trends Endocrinol Metab. 2011 May 18;22(9):345–352. doi: 10.1016/j.tem.2011.04.005

Figure 1. Proposed interplay between HPO axis and spleen.

Figure 1

Preovulatory rise of E2 (estradiol) stimulates release of LH into the bloodstream. Then LH triggers leukocyte release from the spleen either by directly acting on leukocytes or through indirect effects on splenic tissues. Splenic leukocytes released into the bloodstream migrate to the ovary in response to cytokines and chemokines that act as leukocyte attractants, the cells enter the tissue through interactions between leukocyte receptors and adhesion molecules on the endothelial cells.