Table 2.
List of chemokines, chemokine receptors and responsible cells present in the ovary
| Chemokine | Producing cells | Chemokine receptor | Responding cells | References |
|---|---|---|---|---|
| CCL-2 (MCP-1) | Mo/MΦ, cDC, BMDC, GC, GLC, stromal fibroblast | CCR-2a, b, CCR-8, CCR-11 | T, Mo, baso, DC, NK | [23, 31, 118–120] |
| CCL-3 (MIP-1α) | Mo/MΦ, cDC, BMDC, TE, TM, NK, B, GC, GLC | CCR-1, CCR-5 | Mo/MΦ, T, baso, eos, neut, DC, NK, GC, TC | [118–120] |
| CCL-4 (MIP-1β) | Mo/MΦ, cDC, BMDC, TE, TM, NK, B | CCR-5 | Mo/MΦ, cDC, BMDC, B, T, NK, baso, eos, B, GC, TC | [118–120] |
| CCL-5 (RANTES) | Mo/MΦ, cDC, BMDC, TE, GC, TM, NK | CCR-1, CCR-3, CCR-5 | TE, TM, NK, Mo/MΦ, DC, eos, baso, GC, TC | [118–120] |
| CCL-20(MIP-3α/LARC) | Epithelial, GC | CCR-6 | PBMC, TE, TM, NKT, DC, B | [118, 121] |
| CCL25 (TECK) | Mo/MΦ, cDC, BMDC, TC | CCR-9 | MΦ, thymocyte, DC, B | [37, 118] |
| CXCL-1 (Groα) | Mo/MΦ, DC, BMDC, GC | CXCR1, CXCR2 | neut, fibroblast | [20, 118, 120] |
| CXCL-5 (ENA-78) | BMDC | CXCR2 | neut, endo, BMDC | [120] |
| CXCL-8 (IL-8) | Mast, GC, GLC, TC, stromal fibroblast | CXCR1, CXCR2 | neut, baso, T, endo | [20] |
| CXCL-10 (IP-10) | Osteoblasts, BM endo, GC | CXCR3A CXCR3B | T, NK, B, endo, Mo/MΦ, DC, GC | [119, 120] |
| CXCL-12 (SDF-1) | BM reticular, GC, endo, stromal, fibroblast | CXCR4, CXCR7 | CD34+ BM, thymocytes, Mo/MΦ, TE, B, plasma, neut, cDC, BMDC | [122, 123] |
| CX3CL1 (Fractalkine) | Mast cells, GC, TC and stromal fibroblasts, endothelium | CX3CR1 | NK, Mo, neut, Mast, astrocytes, neurons, activated T cells | [118] |
NK, natural killer cell; neut, neutrophil; Mast, mast cell; Mo, monocyte; MΦ, macrophage; TE, effector T-cell; TM, memory T-cell; BMDC, bone marrow derived dendritic cell; cDC, conventional dendritic cell; GC, granulosa cell; TC, theca cell; GCL, granulosa-lutein cell; endo, endothelial cell; baso, basophil; PBMC, polymorphonuclear cell; DC, dendritic cell.