Table 1.
List of all molecules which have been tested for sensitivity to KLK within this study, and their respective membrane localization.
| Molecules affected by KLK | KLK effect | Membrane localization |
|---|---|---|
| GPI-hFR-mGFP | accumulation in plasma membrane | outer leaflet inserted |
| GPI-Trail-GFP | accumulation in plasma membrane | outer leaflet inserted |
| GPI-DAF-GFP | accumulation in plasma membrane | outer leaflet inserted |
| GPI-CD58-GFP | accumulation in plasma membrane | outer leaflet inserted |
| CD59-GFP | accumulation in plasma membrane | outer leaflet inserted |
| Cholera Toxin B | accumulation in plasma membrane | bound to GM1 in outer leaflet |
| Bodipy-GM1 | accumulation in plasma membrane | outer leaflet inserted |
| CD43-YFP | accumulation in plasma membrane | single-pass type I membrane protein |
| CD63-GFP | accumulation in plasma membrane | multi-pass membrane protein |
| 4 + − GFP | cell rupture | inner leaflet associated |
| 8 + − GFP | cell rupture | inner leaflet associated |
| PH-YFP | cell rupture | inner leaflet associated |
| Molecules not affected by KLK | KLK effect | Membrane localization |
| Caveolin-1-GFP | none | inner leaflet inserted |
| Lck-GFP | none | inner leaflet inserted |
| Fyn-YFP | none | inner leaflet inserted |
| Flottilin1-GFP | none | peripheral inner leaflet |
| Flottilin2-GFP | none | peripheral inner leaflet |
| CD71-GFP | none | single-pass type II membrane protein |
| Orai1-GFP | none | multi-pass membrane protein |
| CD147-YFP | none | single-pass type I membrane protein |
| SRBI-GFP | none | multi-pass membrane protein |
| SRBII-GFP | none | multi-pass membrane protein |
| CD3ζ-GFP | none | single-pass type I membrane protein |
| Clathrin light chain-GFP | none | peripheral inner leaflet |
| DiD | none | plasma-membrane integrated |