Fig. 2.

Histology of U87 and hTSC tumors. All images H&E, t tumor, b normal brain. a U87 tumor appears rounded (darker staining regions) with distinct boundaries. b U87 tumor image clearly shows a typical rounded and cleanly demarcated tumor profile. c Closer view of U87 tumor shows very little infiltration of adjacent normal brain. d Overview of hTSC tumor showing highly scattered and invasive tumor with irregular outline (tumor includes darker staining areas) e hTSC tumor invasion into subventricular zone along ventricles. f hTSC tumor cell infiltrate into brain with no clear brain-tumor boundary